what factors among delusion proneness, schizotypy, cognitive biases for psychosis, social cognition, and neurocognition explain higher familial loading across schizophrenia spectrum disorders.

Not Applicable

Conditions: Health Condition 1: F23- Brief psychotic disorderHealth Condition 2: F22- Delusional disordersHealth Condition 3: F28- Other psychotic disorder not due to a substance or known physiological conditionHealth Condition 4: F20- SchizophreniaHealth Condition 5: F21- Schizotypal disorderHealth Condition 6: F29- Unspecified psychosis not due to asubstance or known physiological condition

Registration Number: CTRI/2024/08/072030

Lead Sponsor: eelabh Prajapati

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Person with Schizophrenia

1.Individuals diagnosed with schizophrenia based on ICD-11/ICD-10 (DCR)/DSM 5 criteria for schizophrenia.

2.Age group between 18 to 45 years.

3.Duration of illness =5 years

4.Minimum education level up to 6th standard.

5.Those who would give informed consent for the study.

6.Stable on antipsychotic medication

First Degree Relatives of Schizophrenia

1.Siblings of persons diagnosed with schizophrenia.

2.Subjects aged 18 to 45 years.

3.Those who would give informed consent for the study.

4.Schizophrenia proband also agreeing to participate in the study

Normal Control

1.Subjects aged 18 to 45 years.

2.Minimum Education up to 6th standard.

3.Those who would give informed consent.

4.Kessler (K-10) score less than or equal to 19

5.Fifty percent of the participants will be matched on age and education while the other half will be matched with the siblings.

Exclusion Criteria

Persons with Schizophrenia

1.History of any comorbid psychiatric and neurodevelopmental disorders

2.Significant neurological or medical illness.

3.Electroconvulsive therapy in the past 6 months.

4.Unable to comprehend items and task instructions.

First Degree Relatives

1.History of any psychiatric disorder.

2.Significant neurological or medical illness.

3.Unable to comprehend items and task instructions

Normal Control

1.Present or past history of psychiatric disorder/neurological illness

2.Family history of psychiatric/neurodevelopment disorders.

3.Significant neurological or medical illness.

4.Kessler (K-10) score more than 19.

5.Education below 6th standard.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The study will help us in understanding whether a combination of factors among delusional proneness, schizotypy, cognitive biases for psychosis, social cognition, and neuro-cognition provides a more comprehensive explanation of familial risk for schizophrenia spectrum disorder compared to any single factor alone.Timepoint: 2 years.

Secondary Outcome Measures