Investigation of the Effects of Early Enteral Nutrition on Endoscopic Therapy of Esophagogastric Varices in Liver Cirrhosis:An Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Cirrhosis
- Sponsor
- Qilu Hospital of Shandong University
- Enrollment
- 397
- Locations
- 1
- Primary Endpoint
- rebleeding
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study was to evaluate the safety of early enteral nutrition on endoscopic therapy of esophagogastric varices in Liver Cirrhosis ,and to assess the impact of different eating times on patients, so as to determine the best time for patients to obtain nutrition after surgery.
Detailed Description
For patients with gastroesophageal varices in Liver Cirrhosis,, there is no clear guideline and consensus on when to start eating after endoscopic treatment. In 2015, a randomized controlled study in Taiwan of China confirmed that compared with liquid diet given 48 h after endoscopic treatment, liquid diet given 4 h and started enteral nutrition would not increase the risk of rebleeding, and could improve the nutritional status of patients. However, some patients after endoscopic treatment would suffer from post-sternal pain, abdominal pain, nausea, vomiting and other discomforts, affecting appetite and delay the diet time. Based on the above research background, we observed and evaluated the safety and effectiveness of early enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, and analyzed the influencing factors of enteral nutrition in patients with cirrhotic esophageal and gastric varices after endoscopic treatment, so as to further clarify the optimal time for patients to eat after endoscopic treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with cirrhosis of gastroesophageal varices undergoing endoscopic therapy
Exclusion Criteria
- •Endoscopic treatment of uncontrollable bleeding
- •Accompanied with other endoscopic treatments that need to be fasting
- •With obvious hepatic encephalopathy and liver failure
- •Did not sign the informed consent form and refused to participate
Outcomes
Primary Outcomes
rebleeding
Time Frame: 2 to 30days
the rate of rebleeding after endoscopic therapy