the effect of ondansetron on hypotension due to spinal anesthesia for caesarean section.

Phase 3

Completed

• Conditions: hypotension induced by spinal anesthesia for caeserean section; Anaesthesiology - Other anaesthesiology; Reproductive Health and Childbirth - Childbirth and postnatal care

• Registration Number: ACTRN12613000036718
• Lead Sponsor: Tunisian Military Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

parturients ,who were ASA physical status I, undergoing an elective caesarean section

Exclusion Criteria

Parturients with contraindications to subarachnoid block
(patient refusal, unstable haemodynamics, coagulation
abnormality), history of hypersensitivity to ondansetron or local anaesthetic agents, hypertensive disorders of
pregnancy, cardiovascular insufficiency and parturients receiving selective serotonin reuptake inhibitors

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diastolic blood pressure. [baseline time (before injection of ondonsetron or saline),at the end of spinal injection and every 5 minutes until end of surgey. <br>non invasive blood pressure<br><br><br><br>];neonates pH[at delivery.<br><br>arterial blood gas from umbilical cord];heart rate[baseline time (before injection of ondonsetron or saline),at the end of spinal injection and every 5 minutes until end of surgey. <br><br>electrocardioscope]

Secondary Outcome Measures

Name	Time	Method
maternal oxygen saturation<br>[at time of spinal injection and at 5-min intervals until the end of surgery<br><br>pulse oxymetry];Upper sensory levels<br><br>pinkprick and cold test<br>[5-min intervals from spinal injection to 10 minutes];Nausea and vomiting and pruritis<br><br>spontaneous reporting, clinical manifestations (retching, vomiting or itching) and any request for antiemiting or antihistaminic medications [when occured until 2 days after surgery];systolic blood pressure[baseline time (before injection of ondonsetron or saline),at the end of spinal injection and every 5 minutes until end of surgey. <br><br>non invasive blood pressure];mean blood pressure[baseline time (before injection of ondonsetron or saline),at the end of spinal injection and every 5 minutes until end of surgey. <br><br>non invasive blood pressure];maternal lactates[basliene time (before injection of ondonsetron or saline) and at cutaneous incision<br><br>arterial blood gas];apgar score[at 1,3,5 and 10 minutes after birth]