Feasibility of Partial Nephrectomy (PN) in Renal Cell Carcinoma after down-staging with preoperative targeted therapy in patients not otherwise suitable to P
Phase 3
- Conditions
- Health Condition 1: C649- Malignant neoplasm of unspecifiedkidney, except renal pelvis
- Registration Number
- CTRI/2020/07/026546
- Lead Sponsor
- AIIMS Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Expected reduction of GFR less than 30 ml/minute/1.73 m2 after RN or PN and/or
2) Not suitable for PN due to large tumors size (4 - 7cm) and/or high complexity (R.E.N.A.L. score 10 to 12) and/or hilar tumors location.
3. Histological verification of cRCC.
4. Non- metastatic disease
5.Written informed consent.
Exclusion Criteria
1. Known or suspected allergy to pazopanib
2. History of cerebrovascular accident including transient ischemic attack (TIA), pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months.
3. Hypertension [defined as systolic blood pressure of >=140 mmHg or diastolic blood pressure of >= 90 mmHg in spite of optimal medical management.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method