Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study
Completed
- Conditions
- Obesity
- Registration Number
- NCT02093416
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants.
The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Endoscopic Intervention
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Exclusion Criteria
- 18 years of age or older
- No acute GI bleeding
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PCR test for Leptin Receptors 1 week Endoscopic biopsies of enterocytes will be measured via PCR
- Secondary Outcome Measures
Name Time Method ELISA test for ghrelin, motilin, leptin and PYY 1 week Blood samples collected to determine hormones via ELISA
IWQOL lite questionnaire 1 week Quality of Life questionnaire on obesity
Trial Locations
- Locations (1)
University of Pittsburgh/UPMC Presby
🇺🇸Pittsburgh, Pennsylvania, United States