Local GIT Hormones After Bariatric Maneuvers

Not Applicable

• Conditions: Morbid Obesity
• Interventions: Procedure: sleeve gastrectomy with loop bipartition

• Registration Number: NCT04414072
• Lead Sponsor: Minia University

Brief Summary

Background: Many of the beneficial metabolic effects of bariatric surgery have been attributed to altered peptide hormone profiles, especially involving pancreatic and gut peptides.

Objectives: assess the effects of bariatric procedures (sleeve gastrectomy, minigastric bypass and sleeve gastrectomy with loop bipartition) on GIT hormones. Methods: Prospective randomized study which was carried out in the department of General Surgery, Minia University hospital during the period from February 2018 to February 2019. This study included 3 groups subjected to different operations; each group consisted of 50 patients.

Detailed Description

Prospective randomized study which was carried out in the department of General Surgery, Minia University hospital during the period from February 2018 to February 2019. This study included 3 groups subjected to different operations; each group consisted of 50 patients. Age ranging from 20 to 50 years old and body weight ranging from 100 to 200 Kg, and subjected to laparoscopic sleeve gastrectomy, mini gastric bypass and sleeve gastrectomy with loop bipartition. Each patient was thoroughly evaluated by a multidisciplinary team (Nutritionist, Endocrinologist, Psychologist, and Surgeon) using a standardized protocol. Follow up was done after two weeks and after 2 months.

Study Timeline

• Status Verified: 2020-05
• Study First Submitted: 2020-05-28
• Study First Submitted QC: 2020-05-30
• Last Update Submitted: 2020-05-30
• Study First Posted: 2020-06-04
• Last Update Posted: 2020-06-04
• Study Start: 2021-02-01
• Primary Completion: 2021-02-01
• Study Completion: 2022-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

All morbid obese patients

Exclusion Criteria

GIT diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sleeve gastrectomy with loop bipartition	sleeve gastrectomy with loop bipartition	-
laparoscopic sleeve gastrectomy	sleeve gastrectomy with loop bipartition	-
mini gastric bypass	sleeve gastrectomy with loop bipartition	-

Primary Outcome Measures

Name	Time	Method
hormonal change	one year	GIT hormones (Ghrelin, secretin, PYY, GLP-1)

Trial Locations

Locations (1)

Minia university; 🇪🇬 Minya, Egypt