The pleiotropic metabolic effects of bariatric surgery
- Conditions
- obesitas/hypertensie/glucose en lipiden metabolismemetabolic syndrome
- Registration Number
- NL-OMON33590
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
pre-menopausal Caucasian women scheduled for Roux-en-Y gastric bypass surgery
Exclusion Criteria
any chronical medical condition except for glucose intolerance, hypertension and secondary dyslipidemia
use of medication which interferes with dopamine metabolism
clinically overt atherosclerotic events
claustrophobia and unremovable metal objects
tobacco use (i.e. smokers)
malignant or uncontrolled hypertension (blood pressure >200/120 mmHg or blood pressure >180/110 mmHg with 1 or more drugs, or >160/100 with 2 or more drugs)
unwilling or unable to provide informed consent
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- hypothalamic dopamine receptor binding capacity<br /><br>- insulin sensitivity<br /><br>- inflammatory changes in adipose tissue and liver</p><br>
- Secondary Outcome Measures
Name Time Method <p>- bloodpressure and sympathetic activity<br /><br>- hypothalamic activity (measured with functional MRI)<br /><br>- phenotypical differences (adipose tissue distribution, plasma parameters)</p><br>