Effect of bariatric surgery dependent weight loss on gut barrier function and the inflammatory status
- Conditions
- E66Obesity
- Registration Number
- DRKS00009008
- Lead Sponsor
- Else Kröner-Fresenius Zentrum für Ernährungsmedizn, Lehrstuhl für Ernährungsmedizin, Technische Universität München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
written informed consent, BMI = 40 kg/m² for the bariatric surgery group, BMI < 30 kg/m² for the control group
Exclusion Criteria
absent written informed consent, poor complicance, serious illness, e.g. cancer, COPD, serious hart disease (e.g. pacemaker), serious mental illness, liver illness (AST, ALT > 3fold of normal value), renal disease (creatinine > 1.2 mg/dl), serious gastrointestinal, neurological, rheumatic illness, celiac disease, acute infections, hypokalemia, insulin-dependent diabetes mellitus, regular intake of antibiotics, immunesuppressants, laxatives, anti-diarrhea medication, malabsorption syndrome, autonomic neuropathy, lactulose intolerance, sucralose intolerance, sucrose intolerance
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method intestinal permeability: sugar resorption test;<br>change in microbial composition of the colon: faecal sample, metagenomic sequencing of faecal microbiota; <br>inflammatory parameters in blood: blood samples, CRP;<br>marker of intestinal permeability in blood: blood samples, zonulin and LPS-binding protein;<br>all parameters are measured before as well as six months after sugery in the obese patients and once in the control patients<br>
- Secondary Outcome Measures
Name Time Method anthropometry: body weight as well as waist-to-hip ratio;<br>eating habits: 7 day dietary protocol;<br>fasting insulin, fasting glucose, HbA1c: blood samples, laboratory analysis<br>all parameters are measured before as well as six months after sugery in the obese patients and once in the control patients