Epidemiology and control of schistosomiasis in preschool-aged children in Côte d?Ivoire, with particular consideration to the efficacy and safety of crushed praziquantel tablets
- Conditions
- Schistosomiasis [bilharziasis]SchistosomiasisInfections and Infestations
- Registration Number
- ISRCTN53172722
- Lead Sponsor
- Swiss Tropical and Public Health Institute (Switzerland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 350
1. Both males and females, aged less than or equal to 72 months
2. Written informed consent by parents or legal guardian
3. Submission of two stool samples of sufficient size to prepare duplicate Kato-Katz thick smears from each sample at the baseline survey
4. Submission of two urine samples of sufficient amount for urine filtration method at the baseline survey
5. Provision of single fingerprick blood sample for malaria rapid diagnostic test and haemoglobin level assessment
6. Absence of major systemic illnesses, as assessed by medical personnel on the day of treatment
1. Children aged more than 72 months
2. No written informed consent provided by by parents or legal guardian
3. Submission of less than two stool samples of sufficient size to prepare duplicate Kato-Katz smears from each sample at the baseline or follow-up survey
4. Submission of less than two urine samples of sufficient amount for urine filtration method at the baseline survey
5. No provision of fingerprick blood sample for malaria rapid diagnostic test and haemoglobin level assessment
6. Presence of any abnormal medical condition, as judged by the medical personnel on the day of treatment (e.g. clinical malaria)
7. Recent anthelminthic treatment (within 4 weeks)
8. Participation in other studies
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cure rate and egg reduction rate of S. mansoni and S. haematobium, determined 3-4 weeks post-treatment by multiple stool sampling using the Kato-Katz method and multiple urine filtration tests
- Secondary Outcome Measures
Name Time Method Frequency and severity of adverse events recorded within 24 hours after drug administration