Correlation of subjective pain perception (VAS) and contact heat evoked potentials (CHEP) under remifentanil induced analgesia - with concomitant rating of vigilance by auditory evoked potentials (AEP) and OAA/S-score and analysis of synergistic drug effects on CHEP during propofol-induced loss of consciousness

Not Applicable

Recruiting

Conditions: pain during anesthesia
R52.9
Pain, unspecified

Registration Number: DRKS00003300

Lead Sponsor: Zentrum für Anästhesiologie, Helios Klinikum Wuppertal, Universität Witten/Herdecke

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 120

Inclusion Criteria

ASA physical status 1-2 (classification system to assess fitness of patients before surgery): correlates with healthy patients (ASA 1) and patients with mild systemic disease (ASA 2), written consent, mental capacity, age: 18-50 years

Exclusion Criteria

cardiac, hepatic, renal, pulmonary or gastrointestinal diseases, disorders of gastrointestinal motility, psychiatric and neurologic diseases, altered cerebral perfusion, chronic intake of drugs, psychotropics or other substances with central- or peripheral nervous effects, hypacusis and deafness, analgetic long-term medication, chronic pain, agitated or anxious patients, allergy, known intolerance and contraindications against the used drugs, pregnancy

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
correlation between individual pain perception (described by visual analogue scale, VAS) and CHEP-amplitudes (Contact Heat Evoked Potentials) as the electroencephalographic correlate of the applied heat pain under remifentanil als analgesic. Remifentanil-induced changes of VAS and CHEP will be compared to the baseline measurement without drug application and will be analyzed under four different remifentanil-concentrations.

Secondary Outcome Measures

Name	Time	Method
- correlation between remifentanil concentration and reduction of CHEP (Contact Heat Evoked Potential)-amplitudes<br>- registration of potential sedative effects of remifentanil by AEP (auditory evoked potentials) and OAA/S-score (Observer's Assessment of Alertness/Sedation-score)<br>- effects of loss of consciousness on CHEP (Contact Heat Evoked Potential)<br>- gender-related differences on CHEP (Contact Heat Evoked Potential)