Effect of Dexmedetomidine and Sevoflurane on the quality of recovery and cognitive function after general anaesthesia
Phase 4
- Conditions
- Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhereHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2024/07/070550
- Lead Sponsor
- ttar Pradesh University of Medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Adult subjects classified as American Society of Anaesthesiologists (ASA) I-II.2.Non-obese individuals with a body mass index (BMI) below 30kg/m2.3.Mini-Mental State Examination(MMSE) score 25 preoperatively.4.Patients undergoing general anaesthesia of more than 2 hours and less than 6 hours at UPUMS hospital.
Exclusion Criteria
1.Patient refusal.
2.Presence of health conditions(e.g.cardiac, pregnancy, pulmonary diseases,neurological condition)
3.Visual/hearing impairment, smoking/alcohol abuse, cognitive dysfunction.
4.Mini-Mental State Examination (MMSE) score less than 25 preoperatively.
5.Any known allergy to drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of Dexmedetomidine and Sevoflurane on QoR-15(Quality of recovery questionnaire)Timepoint: Preoperatively (30 min before surgery) <br/ ><br>Post-operative Day-1 <br/ ><br>Post-operative Day -2 <br/ ><br>At the day of discharge
- Secondary Outcome Measures
Name Time Method 1.Comparison of Dexmedetomidine and Sevoflurane on MMSE(Mini mental state examination) <br/ ><br>2.Comparison of hemodynamic parameters <br/ ><br>3.Comparison of emergence agitation <br/ ><br>4.comparison of side effect and any complicationsTimepoint: 1.Post-operative Day-1 <br/ ><br>2.Intraoperatively <br/ ><br>3.After two minutes after extubation <br/ ><br>4.Intra-operative and Post-operative