Perioperative Low-dose Dexmedetomidine Decreases Incidence of Delirium in Liver Transplant Patients
Overview
- Phase
- Phase 4
- Intervention
- placebo control
- Conditions
- Liver Transplantation
- Sponsor
- Seoul National University Hospital
- Enrollment
- 217
- Locations
- 1
- Primary Endpoint
- analysis of the incidence of postoperative delirium in liver transplant patients in the ICU.
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
To test the effect of low-dose dexmedetomidine for lowering the incidence of postoperative delirium in liver transplant patients in the ICU.
Single center prospective randomized placebo controlled clinical trial 0.1mcg/kg/hr of dexmedetomidine or equivalent amount of saline infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
Outcomes will be assessed up to 1 week or transfer to ward, whichever comes first.
Investigators
Ho Geol Ryu
assistant professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult patients (18years old or older) undergoing living-donor or deceased-donor liver transplantation
Exclusion Criteria
- •Pediatric patients (under 18 years) Pregnancy Patients who are unresponsive at baseline, who have neurologic deficits at baseline, or who are allergic to dexmedetomidine
Arms & Interventions
Normal saline
same infusion rate as experimental group (dexmedetomidine)
Intervention: placebo control
dexmedetomidine
0.1mcg/kg/hr of dexmedetomidine infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
Intervention: Precedex
Outcomes
Primary Outcomes
analysis of the incidence of postoperative delirium in liver transplant patients in the ICU.
Time Frame: 1 week or transfer to ward, whichever comes first.
after August 25, 2014
Secondary Outcomes
- analysis of the duration of postoperative delirium, ICU length of stay in liver transplant patients in the ICU.(1 week or transfer to ward, whichever comes first.)