Perioperative Low-dose Dexmedetomidine Decreases Incidence of Delirium in Liver Transplant Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 217
- 试验地点
- 1
- 主要终点
- analysis of the incidence of postoperative delirium in liver transplant patients in the ICU.
研究概览
简要总结
To test the effect of low-dose dexmedetomidine for lowering the incidence of postoperative delirium in liver transplant patients in the ICU.
Single center prospective randomized placebo controlled clinical trial 0.1mcg/kg/hr of dexmedetomidine or equivalent amount of saline infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
Outcomes will be assessed up to 1 week or transfer to ward, whichever comes first.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (18years old or older) undergoing living-donor or deceased-donor liver transplantation
排除标准
- •Pediatric patients (under 18 years) Pregnancy Patients who are unresponsive at baseline, who have neurologic deficits at baseline, or who are allergic to dexmedetomidine
研究组 & 干预措施
Normal saline
same infusion rate as experimental group (dexmedetomidine)
干预措施: placebo control (Drug)
dexmedetomidine
0.1mcg/kg/hr of dexmedetomidine infusion started after induction of anesthesia for liver transplantation and continued until 48 hours after surgery.
干预措施: Precedex (Drug)
结局指标
主要结局
analysis of the incidence of postoperative delirium in liver transplant patients in the ICU.
时间窗: 1 week or transfer to ward, whichever comes first.
after August 25, 2014
次要结局
- analysis of the duration of postoperative delirium, ICU length of stay in liver transplant patients in the ICU.(1 week or transfer to ward, whichever comes first.)
研究者
Ho Geol Ryu
assistant professor
Seoul National University Hospital