Ultrasound-Guided TAP Block and Spinal Morphine for Pain Relief After Caesarean Section

Not Applicable

Completed

• Conditions: Post Operative Pain
• Interventions: Procedure: Ultrasound-Guided Transversus Abdominis Plane Block; Drug: Morphine

• Registration Number: NCT05331781
• Lead Sponsor: Sohag University

Brief Summary

This interventional double-blind randomized controlled study was carried out on 60 cases underwent elective caesarean section delivery, they were divided into 2 groups; patients were randomly allocated into two equal groups; Group M: received intrathecal 150 microgram morphine in a 0.5 ml volume, mixed with 10 mg of hyperbaric bupivacaine 0.5 % in a 2 ml volume (total volume 2.5 ml). Group B: received intrathecal 10 mg hyperbaric bupivacaine 0.5% 2ml volume + 0.5 saline (Total volume 3ml) and at the end of surgery patient received bilateral TAP block with 20 ml volume of 0.25% bupivacaine on each side.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Primary Completion: 2021-01-01
• Study Completion: 2022-02-01
• Status Verified: 2022-04
• Study First Submitted: 2022-04-02
• Study First Submitted QC: 2022-04-09
• Last Update Submitted: 2022-04-09
• Study First Posted: 2022-04-18
• Last Update Posted: 2022-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• pregnant females scheduled for elective cesarean section

Exclusion Criteria

• Patient refusal Patients with known allergies or with past history of allergy to local anesthesia Patients having an infection at the site of injection either in the back or in the abdominal region, Patients with coagulopathy or on systemic anticoagulation, Chronic opioid abuse, significant neurological, psychiatric or neuromuscular disease, Drug abuse and alcoholism, Obesity (BMI 30 and higher), Cardiovascular disease and Endocrine disorders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
transversus abdominis plain block group	Ultrasound-Guided Transversus Abdominis Plane Block	post-cesarean section tap block will be given by ultrasound guidance using 20 ml bupivacaine local anesthetic 0.25% concentration for each side as an adjuvant to spinal anesthesia
intrathecal morphia group	Morphine	intrathecal 150 microgram morphine in a 0.5 ml volume as an adjuvant to spinal anesthesia

Primary Outcome Measures

Name	Time	Method
prevention of post-operative pain	72 hours	reduction of visual analogue scale post-operative

Trial Locations

Locations (1)

Faculty of Medicine, Sohag University; 🇪🇬 Sohag, Egypt