Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorp...

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Intravenous Methadone for Sternotomy Pain Control in Cardiac Surgery

Phase 3

Recruiting

Conditions: Pain, Postoperative

Interventions: Drug: Methadone
Drug: Morphine

First Posted Date: 2024-12-11

Last Posted Date: 2024-12-11

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 86

Registration Number: NCT06728371

Locations: 🇭🇰
Prince of Wales Hospital, Hong Kong, Hong Kong

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

Phase 2

Not yet recruiting

Conditions: Primary Total Knee Arthroplasty
Intraosseous Morphine Injection
Knee Osteoarthritis

Interventions: Drug: Vancomycin
Drug: Morphine

First Posted Date: 2024-12-04

Last Posted Date: 2024-12-04

Lead Sponsor: Carilion Clinic

Target Recruit Count: 86

Registration Number: NCT06716749

Locations: 🇺🇸
Carilion Clinic, Roanoke, Virginia, United States

A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery

Phase 2

Active, not recruiting

Conditions: Pain

Interventions: Drug: YZJ-4729
Drug: placebo
Drug: morphine

First Posted Date: 2024-11-08

Last Posted Date: 2024-11-08

Lead Sponsor: Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Target Recruit Count: 179

Registration Number: NCT06680466

Locations: 🇨🇳
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China

Effect of Unilateral Erector Spinae Plane Block Versus Intrathecal Morphine on Early Mobilization After Hip Replacement

Early Phase 1

Conditions: Pain, Postoperative

Interventions: Procedure: erector spinae plane block
Drug: Morphine

First Posted Date: 2024-10-01

Last Posted Date: 2024-10-01

Lead Sponsor: Cairo University

Target Recruit Count: 70

Registration Number: NCT06621849

Locations: 🇪🇬
Faculty of Medicine- Cairo University, Cairo, Egypt

Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery

Phase 4

Not yet recruiting

Conditions: Intraoperative Pain

Interventions: Drug: Morphine
Drug: Fentanyl-Morphine

First Posted Date: 2024-08-26

Last Posted Date: 2024-10-01

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 186

Registration Number: NCT06570343

Effectiveness of Ultrasound-Guided Erector Spinae Plane Block for Postoperative Pain Control in Open Knee Surgeries

Not Applicable

Not yet recruiting

Conditions: Knee Injuries

Interventions: Procedure: erector spinea plane block
Drug: Morphine Sulfate

First Posted Date: 2024-08-20

Last Posted Date: 2024-10-30

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT06562634

Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients

Phase 4

Not yet recruiting

Conditions: Effect of Drug

Interventions: Drug: Fentanyl
Drug: Morphine

First Posted Date: 2024-06-28

Last Posted Date: 2024-06-28

Lead Sponsor: Universiti Sains Malaysia

Target Recruit Count: 116

Registration Number: NCT06479655

Locations: 🇲🇾
Mohd Zulfakar Mazlan, MBBS, Kota Bharu, Kelantan, Malaysia

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine

Phase 3

Not yet recruiting

Conditions: Limb Injury

Interventions: Drug: Morphine
Drug: IN fentanyl
Drug: IN ketamine
Drug: NaCl 0,9 %

First Posted Date: 2024-06-18

Last Posted Date: 2024-06-18

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 300

Registration Number: NCT06464146

Locations: 🇫🇷
Hopital Necker Enfants malades, Paris, France

To Evaluate the Efficacy and Safety of Tegileridine and Oliceridine Injections in the Treatment of Postoperative Pain

Phase 4

Not yet recruiting

Conditions: Analgesia

Interventions: Drug: Tegileridine
Drug: Oliceridine
Drug: Morphine

First Posted Date: 2024-06-13

Last Posted Date: 2024-06-13

Lead Sponsor: Yuwei Qiu

Target Recruit Count: 75

Registration Number: NCT06458400

Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries

Phase 2

Recruiting

Conditions: Pericapsular Nerve Group Block

Interventions: Procedure: Ultrasound-guided Combined Pericapsular Nerve Group Block
Procedure: Caudal epidural analgesia
Procedure: Ultrasound-guided Lateral Femoral Cutaneous Nerve Block
Drug: Fentanyl
Drug: Morphine
Drug: Acetaminophen

First Posted Date: 2024-05-16

Last Posted Date: 2024-05-16

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 68

Registration Number: NCT06417268

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

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