临床试验/NCT04892810

NCT04892810已完成不适用

Immunomonitoring of Interventional Radiology Procedures in the Management of Hepatocellular Carcinoma

University Hospital, Grenoble1 个研究点分布在 1 个国家目标入组 20 人开始时间: 2022年2月3日最近更新: 2026年7月22日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 20
试验地点: 1
主要终点: To compare induced immunomodulation by RFA and MWA in HCC patients

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This cohort study compares immune response induced in two groups of small HCC patients treated by ablation (group1 RFA, group 2 MWA). Patients will benefit for tumoral and non tumoral biopsies prior to treatment and stepped peripheral blood samples juste before ablation and during the first month after.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 40 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Histologically proven HCC for less than 3 months before ablation
•Decision of ablation treatment in multidisciplinary meeting

排除标准

•Fibrolamellar HCC
•Hepatocholangiocarcinoma

结局指标

主要结局

To compare induced immunomodulation by RFA and MWA in HCC patients

时间窗: one month

Comparison of modulation of immune cells (frequency, activity, function) between the two groups. Study of immune cells will include T cells with immune checkpoints molecules (PD-1+ CD8+ T, 4-1BB+ CD8+ T, LAG-3+ CD8+ T, Tim-3+ CD8+ T, COS+ CD8+ T) before and after the treatment (day 0, day 2, day 7, day 30)

次要结局

To evaluate early induced immunomodulation after RFA in HCC patients(one month)
To evaluate early induced immunomodulation after MWA in HCC patients(one month)

研究者

发起方

University Hospital, Grenoble

申办方类型

Other

责任方

Sponsor

研究点 (1)

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