NCT04892810已完成不适用
Immunomonitoring of Interventional Radiology Procedures in the Management of Hepatocellular Carcinoma
University Hospital, Grenoble1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2022年2月3日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- To compare induced immunomodulation by RFA and MWA in HCC patients
研究概览
简要总结
This cohort study compares immune response induced in two groups of small HCC patients treated by ablation (group1 RFA, group 2 MWA). Patients will benefit for tumoral and non tumoral biopsies prior to treatment and stepped peripheral blood samples juste before ablation and during the first month after.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically proven HCC for less than 3 months before ablation
- •Decision of ablation treatment in multidisciplinary meeting
排除标准
- •Fibrolamellar HCC
- •Hepatocholangiocarcinoma
结局指标
主要结局
To compare induced immunomodulation by RFA and MWA in HCC patients
时间窗: one month
Comparison of modulation of immune cells (frequency, activity, function) between the two groups. Study of immune cells will include T cells with immune checkpoints molecules (PD-1+ CD8+ T, 4-1BB+ CD8+ T, LAG-3+ CD8+ T, Tim-3+ CD8+ T, COS+ CD8+ T) before and after the treatment (day 0, day 2, day 7, day 30)
次要结局
- To evaluate early induced immunomodulation after RFA in HCC patients(one month)
- To evaluate early induced immunomodulation after MWA in HCC patients(one month)
研究者
研究点 (1)
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