Effect of N-acetylcysteine on Hydrogen Sulfide in Chronic Kidney Disease
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Hydrogen sulfide (H2S)
研究概览
简要总结
Cardiovascular morbidity and mortality is high in CKD patients. Nitric oxide (NO) deficiency plays a crucial role in progression of CKD. This leads to endothelial dysfunction, hypertension, and inflammation. Hydrogen sulfide (H2S) could serve as a backup mechanism for NO deficiency in CKD. N-acetylcysteine (NAC) is a derivate of cysteine and this is the main substrate for H2S production. Therefore, NAC should enable us to stimulate H2S production in humans. Our objective is to investigate the effect of NAC on plasma H2S levels and on markers of oxidative stress, inflammation, and endothelial dysfunction in healthy volunteers, CKD patients, and dialysis patients. We hypothesize that there is an increase in H2S levels after treatment with NAC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Healthy volunteers
干预措施: N-acetylcysteine (Drug)
CKD patients
Patients with CKD stage 3-4 (GFR 15-60 ml/min)
干预措施: N-acetylcysteine (Drug)
Hemodialysis patients
干预措施: N-acetylcysteine (Drug)
Peritoneal dialysis patients
干预措施: N-acetylcysteine (Drug)
结局指标
主要结局
Hydrogen sulfide (H2S)
时间窗: After 48 hours
Investigate the effect of N-acetylcysteine on plasma H2S levels and on markers of oxidative stress, inflammation, and endothelial dysfunction in healthy volunteers, CKD patients, and dialysis patients
次要结局
未报告次要终点
研究者
A.C. Abrahams
MD
UMC Utrecht