To evaluate different forms of liposomal Amphotericin B namely sonicated gel, unsonicated drop and sonicated drop for the treatment of fungal keratitis
Phase 1
Completed
- Conditions
- Health Condition 1: H160- Corneal ulcer
- Registration Number
- CTRI/2020/04/024550
- Lead Sponsor
- Ocular pharmacology aiims
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
ADULTS PATIENT MORE THAN OR EQUAL TO 18 YEARS
KOH SMEAR POSITIVE FOR FUNGAL KERATITIS
PATIENTS WILLING TO GIVE INFORMED CONSENT
PATIENTS WILLING TO FOLLOW UP
FUNGAL HYPHAE POSITIVE ON CONFOCAL MICROSCOPY
Exclusion Criteria
IMPENDING PERFORATION, CORNEAL PERFORATION
EVIDENCE OF BACTERIA ON GRAM STAIN AT THE TIME OF ENROLLMENT
BILATERAL ULCER
ALLERGIC TO STUDY MEDICATIONS
NO LIGHT PERCEPTION IN THE AFFECTED EYE
PREGNANT OR LACTATING FEMALE
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TIME TO RESOLUTION OF EPITHELIAL DEFECT <br/ ><br>TIME TO RESOLUTION OF CORNEAL INFILTRATES <br/ ><br>TIME TO RESOLUTION OF HYPOPYONTimepoint: 3 MONTH
- Secondary Outcome Measures
Name Time Method CORNEAL OPACITY AT THE END OF 3 MONTHS AFTER ENROLLMENT <br/ ><br>CORNEAL VASCULARISATION AT THE END OF 3 MONT AFTER ENROLLMENT <br/ ><br>BEST CORRECTED VISUAL ACQUITY AT THE END OF 3 MONT AFTER ENROLLMENTTimepoint: 3 MONTH