Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- Corporacion Parc Tauli
- Enrollment
- 612
- Locations
- 8
- Primary Endpoint
- 28-day mortality
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality in ICU COVID-19 patients.
Detailed Description
After giving consent to participate in the study, the subjects included in the study will undergo a 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline stable StO2 value is obtained, a provocative test, consisting of a transient vascular occlusion, will be performed. The test will allow the obtention of a local metabolic rate, and a StO2 recovery rate after the ischemic stimulus. This StO2 recovery rate will be considered as a reflection of the endothelial health of the patient. Patients will be studied as soon as possible after admission to the ICU, and followed-up until ICU discharge or death.
Investigators
Jaume Mesquida
MD, PhD
Corporacion Parc Tauli
Eligibility Criteria
Inclusion Criteria
- •Recent diagnosis of SARS-CoV2 infection
- •Arterial hypoxemia and bilateral alveolar infiltrates, not explained by cardiac dysfunction or fluid overload.
Exclusion Criteria
- •Severe peripheral vasculopathy
- •Raynaud's syndrome
- •Skin lesions or trauma in upper limbs interfering the placement of NIRS probe and/or the occlusion tourniquet
- •Deep venous thrombosis in the upper limbs
Outcomes
Primary Outcomes
28-day mortality
Time Frame: 28 days
Mortality at 28 days of patients admitted to the ICU as results of respiratory failure secondary to COVID-19