Evaluation and testing of the microvascular function in asymptomatic athletes

Withdrawn

• Conditions: Microvasculair function; the function of the smaller cardiac blood vessels; 10028593

• Registration Number: NL-OMON46277
• Lead Sponsor: Maxima Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Asymptomatic athletes with normal exercise electrocardiography results and asymptomatic athletes with concordant abnormal exercise electrocardiography results and abnormal myocardial perfusion scintigraphy results but without the presence of epicardial coronary artery disease.;An athlete is defined as a sportsmen who is engaged in sports for at least 2.5 hours a week for a period of minimally 30 weeks per year or in two or more sports with a minimum of 1.5 hours per week within one type of sports for at least 20 weeks per year

Exclusion Criteria

Symptomatic athletes ((Exercise induced) chest pain, palpitations, dizziness, light headiness or syncope), athletes with epicardial coronary artery disease, athletes with previous myocardial infarction

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters:<br /><br><br /><br>* Myocardial blood flow (MBF) per gram of myocardial tissue (ml/min/g) with<br /><br>82Rb PET-CT imaging.<br /><br>* Myocardial flow reserve (MBF at peak hyperaemia / MBF at rest) with 82Rb<br /><br>PET-CT imaging.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters:<br /><br><br /><br>* The plasma levels of eNOS and ET-1 in athletes with a normal and abnormal<br /><br>exercise test result. </p><br>