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Clinical Trials/NL-OMON37954
NL-OMON37954
Completed
N/A

Assessment of microvascular alterations in patients with angina pectoris and no evidence of significant coronary artery disease - Glycocalyx perturbation in patients with microvascular angina pectoris

Medisch Universitair Ziekenhuis Maastricht0 sites60 target enrollmentTBD
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ConditionsAtherosclerosis1001108210003216

Overview

Phase
N/A
Intervention
Not specified
Conditions
Atherosclerosis
Sponsor
Medisch Universitair Ziekenhuis Maastricht
Enrollment
60
Status
Completed
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
last year
Study Type
Observational non invasive

Investigators

Sponsor
Medisch Universitair Ziekenhuis Maastricht

Eligibility Criteria

Inclusion Criteria

  • •Subjects who want to participate in the study should be over 18 years of age and be able to give informed consent.;Patients with coronary artery disease:
  • •These patients should have proven coronary artery disease, defined as \>\=50% diameter stenosis objectified by coronary angiography. ;Patients with suspected small vessel disease:
  • •These patients should have a positive exercise ECG but no evidence of significant coronary artery disease on their coronary angiogram. ;The time between the coronary angiogram and the MR perfusion scan and OPS imaging cannot exceed one year. It can be reasonably expected that the status of the coronaries will not have changed significantly over this time period if the symptoms of angina have not changed. ;Healthy controls:
  • •These subjects must be free of angina pectoris or (a history of) coronary artery disease.

Exclusion Criteria

  • •Patients:;General:
  • •\- Age \< 18 years.
  • •\- Unable to give informed consent.;Other cardiac pathology:
  • •\- Atrial fibrillation.
  • •\- Unstable angina pectoris (persistent CCS class IV despite medical treatment).
  • •\- Cardiogenic shock.
  • •\- Congestive heart failure NYHA class \>\=III. ;Contraindication to adenosine side effects:
  • •\- AV\-block (2nd or 3rd degree).
  • •\- Severe asthma.
  • •\- COPD Gold IV.;General contra\-indications to MR imaging

Outcomes

Primary Outcomes

Not specified

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