The assessment of microvascular alterations in renal transplant recipients with and without rejection - OPS-1

eids Universitair Medisch Centrum0 个研究点目标入组 105 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Inclusion criteria for renal transplant patients:
•1. Age: 18 -70 years
•2. Female or male
•3. Kidney transplantation( living and cadaveric)
•4. Patients who will undergo renal biopsy because of renal function impairment
•5. Patients must be able to adhere to the study visit schedule and protocol requirements.
•6. Patients must be able to give informed consent and the consent must be obtained prior to any study procedure.;Inclusion criteria for healthy controls:
•1. Age: 18-70
•2. Female or male

•Exclusion criteria for renal transplant patients:
•1. Double organ transplantation
•2. Patients with evidence of active infection or abcesses.
•3. Patients suffering from hepatic failure.
•4. Patients suffering from an active autoimmune disease
•5. Malignancy (including lymphoproliferative disease) within the past 2-5 years (except for squamous or basal cell carcinoma of the skin that has been treated with no evidence of recurrence)
•6. Patients who currently have an active opportunistic infection (e.g., herpes zoster [shingles], cytomegalovirus (CMV), Pneumocystis carinii (PCP), aspergillosis, histoplasmosis, or mycobacteria other than TB)
•7. Patients with epilepsy;Exclusion criteria for healthy controls:
•1. Smoking (within 1 year prior to screening)
•2. History of cardiovascular disease
•3. History of malignancy
•4. Use of any investigational agent in the last 30 days
•5. History of chronic inflammatory disease
•6. History of chronic skin diseases
•7. History of diabetes mellitus
•8. History of alcohol or drug abuse within the last 5 years
•9. Hypertension

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