Tailored Internet-delivered Cognitive Behaviour Therapy for Symptoms of Depression and Comorbid Problems

Not Applicable

Completed

• Conditions: Depression; Anxiety Disorders
• Interventions: Behavioral: Tailored Internet-delivered CBT; Behavioral: Non-tailored Internet-delivered CBT; Behavioral: Online discussion group

• Registration Number: NCT01181583
• Lead Sponsor: Linkoeping University

Brief Summary

The overall aim of this study is to develop and test a tailored Internet-delivered psychological treatment for patients with mild to moderate major depression and comorbid anxiety symptoms and compare its efficacy to a non-tailored treatment and to an active control group.

Detailed Description

Internet-delivered cognitive behaviour therapy (CBT) has emerged as a promising way to administer evidence-based psychological treatments. Mild to moderate major depression has previously been found to treatable via the Internet, with the provision that minimal therapist guidance is given. However, previous research has not taken the issue of comorbidity into account. It is well known that major depression often is accompanied by anxiety and in addition the symptom profile in major depression may differ substantially. The idea behind the proposed research is to tailor the Internet intervention according to the symptom profile. By used a large set of treatment modules (text-based) we aim to diagnose and then prescribe modules. In a randomized trial we want to compare this procedure (e.g., tailored CBT) with the standard Internet-delivered CBT. We will also include a control group in the form of a supervised online discussion group who will later receive CBT.

Study Timeline

• Study First Submitted: 2010-08-09
• Study First Submitted QC: 2010-08-12
• Study First Posted: 2010-08-13
• Status Verified: 2010-12
• Last Update Submitted: 2010-12-27
• Last Update Posted: 2010-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

• Clinical diagnosis of Major Depressive Disorder
• 15 or more on MADRS-S

Exclusion Criteria

• Severe depression (more than 35 on MADRS-S or based on interview)
• Severe psychiatric condition (e.g. psychosis or bipolar disorder)
• Changed medication during the last three months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Tailored Internet-delivered CBT	Tailored Internet-delivered CBT	-
Non-tailored Internet-delivered CBT	Non-tailored Internet-delivered CBT	-
Online discussion group	Online discussion group	-

Primary Outcome Measures

Name	Time	Method
Beck Depression Inventory (BDI)	2 years after treatment ended

Secondary Outcome Measures

Name	Time	Method
Beck Anxiety Inventory (BAI)	2 years after treatment ended
Montgomery Åsberg Depression Rating Scale Self-report (MADRS-S)	2 years after treatment ended
Quality of Life Inventory (QOLI)	2 years after treatment ended

Trial Locations

Locations (1)

Linköping University, Department of Behavioral Sciences and Learning; 🇸🇪 Linköping, Sweden