Association Between House Dust Mites Sensitization and Level of Asthma Control and Severity in Children Attending Mansoura University Children's Hospital.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Assessment of asthma severity and level of control.
研究概览
简要总结
In this study we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines.
详细描述
This is an observational, case control study. The study was carried out in Allergy, Clinical Immunology and pediatric pulmonology Unit; at Mansoura University Children Unit during the years 2018-2019. The study included 60 children above 6 years with atopic asthma. They were 42 males and 18 females, their age ranged from 8-17 years. Bronchial asthma diagnosis was based on clinical manifestations and spirometry results. Atopy was defined as presence of symptoms of atopic dermatitis, allergic rhino conjunctivitis, or food allergy, it was confirmed when asthmatic children fulfilled one of the following criteria: higher serum level of total IgE (more than 32IU/ml), eosinophilia (differential count more than 5% or absolute count more than 450/µl) or positive skin prick test (3 mm greater than control).
Asthmatic children were maintained on controller therapy for at least 6 months. They were classified according to skin prick test results into two groups:
- Group1: It included 30 atopic asthmatic children, who were sensitive to one of the two HDM (D pteronyssinus or D farina).
- Group2: It included 30 atopic asthmatic children who were not sensitive to HDM allergy.
- Sampling Samples were convenient and patients were enrolled in the study by consecutive manner.
history taking
- Personal and demographic data e.g. age, sex and residence.
- Asthma symptoms; cough, wheeze, as well as exercise-induced asthma.
- Symptoms of other atopic diseases in the child including allergic march.
- Based on frequency of each symptom, assessment of asthma control was done according to GINA 2017.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age more than 6 years.
- •Asthmatic children with history of atopy (atopic dermatitis, allergic rhinitis or food allergy).
排除标准
- •Other diseases which influence bronchial symptoms and/or lung function.
- •Patients weren't compliant with asthma therapy.
- •Refused the informed consent.
结局指标
主要结局
Assessment of asthma severity and level of control.
时间窗: 1 year
. Patient maintained on step 2 treatments are often classified as having mild asthma. Those receive step 3-4 as moderate asthma and those prescribed step 4-5 as having moderate to severe asthma. Based on asthma control score according to GINA guideline defined as controlled, partially controlled and well controlled
次要结局
未报告次要终点
研究者
Engy Osman Ahmed
Assistant professor of pediatrics, allergy and clinical immunology unit.
Mansoura University Children Hospital