The Role of Taurine in Periodontitis and Aging: a Preliminary Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Taurine
研究概览
简要总结
Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 26 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Exclusion Criteria:
- •ages 18-25 or 45-64
- •use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
- •presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
- •pregnancy or lactation
- •alcoholism
- •nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
- •having less than 20 natural teeth, excluding third molars
- •use of orthodontic appliances
排除标准
- •ages 18-25 or 45-64
- •use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
- •presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
- •pregnancy or lactation
- •alcoholism
- •nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
- •having less than 20 natural teeth, excluding third molars
- •use of orthodontic appliances
结局指标
主要结局
Taurine
时间窗: 12 Weeks
Taurine levels in saliva and serum were measured
SIRT1
时间窗: 12 Weeks
SIRT1 levels in saliva and serum were measured
TNF-α
时间窗: 12 Weeks
TNF-α levels in saliva and serum were measured
次要结局
未报告次要终点
研究者
Hadi Sayedyousef
Phd candidate
Istanbul Medipol University Hospital