Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR).
研究概览
简要总结
Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.
详细描述
Objective
To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation.
Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p < 0.05).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Supplement capsule packages were labeled as "Supplement A" and "Supplement B" and the nutrient (taurine or placebo- starch) was revealed after the end of the intervention.
入排标准
- 年龄范围
- 55 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Had being aged 55-70 years;
- •Post-menopausal;
- •Sedentary (not practicing physical exercise for at least 6 months).
排除标准
- •Chronic kidney diseases;
- •Infectious contagious diseases;
- •Coronary heart disease;
- •Alcoholics.
结局指标
主要结局
Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR).
时间窗: sixteen weeks
Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline.
Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD).
时间窗: sixteen weeks
The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline.
Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA).
时间窗: sixteen weeks
The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline.
次要结局
未报告次要终点
研究者
Ellen Cristini de Freitas
Principal Investigator
University of Sao Paulo