Compare Mitomycin C with Bevacizumab-methycelluse Mixture in Cataract and Glaucoma surgery

Not Applicable

• Conditions: Glaucoma.; Primary open-angle glaucoma Glaucoma (primary)(residual stage): capsular with pseudoexfoliation of lens chronic simple low-tension pigmentary; H40,H41,H4

• Registration Number: IRCT2016122231450N2
• Lead Sponsor: Vice Chancellor for research of Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

The need for cataract surgery in patients with open-angle glaucoma that have glaucomatous progressive cupping and deterioration of the visual field; Diagnosis of open-angle glaucoma on maximally tolerated medical therapy with uncontrolled IOP; The need for cataract surgery in patients with open-angle glaucoma requiring multiple medications to control IOP; Patients suffering from glaucoma and cataract with impaired vision; Patients’ willingness to participate in the study.
Exclusion criteria: Patients with contraindications to bevacizumab such as arterial thromboembolic events, uncontrolled hypertension, and congestive heart failure,..; Discernable congenital abnormality of the anterior chamber angle; Ocular infection; Previous ocular surgery; Uveitis; Corneal diseases that could affect IOP or its measurement such as corneal opacity, large pterygium, ...; Patients who are less than 40 years? Diabetes; Neovascular glaucoma? Patient with any systemic or ocular complication.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intraocular pressure. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Goldmann applanation tonometry (mmHg).

Secondary Outcome Measures

Name	Time	Method
Visual acuity. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Snellen charts.;Visual field. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Humphrey 24-2 SITA Standard perimetry (HFA 24-2) Or(HFA 10-2).;Beleb morphology. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Moorfields Bleb Grading System.;Endophthalmitis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.;Conjunctival necrosis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.;Hypertension. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Sphygmomanometer.