Physiological Effects of ANGPTL3 Variants in Humans
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- The role of ANGPTL3 on lipid metabolism.
研究概览
简要总结
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
详细描述
Oral fast tolerance test, lipoprotein kinetics and a glucose tolerance test to evaluate the role of ANGPTL3, on lipid metabolism and to explore the role of this protein on glucose metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects aged 18 or older meeting at least one of the following criteria
- •Carrying genetic variants in the gene encoding for ANGPTL3,
- •Unaffected controls matched for age, race, gender,
- •Willing to follow study procedures
- •Able to provide inform consent
排除标准
- •Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- •Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- •Women that are pregnant or nursing
- •History of liver disease or abnormal liver function tests (>2x upper limit of normal)
- •History of kidney disease or chronic renal insufficiency (eGFR <60 mL/min/1.73 m2)
- •Uncontrolled hypertension (>160/100 mmHg)
- •Uncontrolled diabetes
- •Anemia (hemoglobin <11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
- •History of any organ transplant
- •History of alcohol or drug abuse
- •Participation in clinical trials assessing the efficacy and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- •Inability to comply to study procedures
结局指标
主要结局
The role of ANGPTL3 on lipid metabolism.
时间窗: through study completion, an average of 13 weeks
Assessing ApoB-containing lipoprotein fractional catabolic rate
The role of this protein on glucose metabolism.
时间窗: through study completion, an average of 13 weeks
Looking for glucose area under the curve following Oral Glucose Tolerance Test
The role of ANPTL3 on fatty acids
时间窗: through study completion, an average of 13 weeks
Looking for fatty acids area under the curve following Oral Fat Tolerance Test
次要结局
未报告次要终点