A Clinical trial on viswathiya choornam in the management of uthiravatha suronitham( Rheumatoid Arthritis)
Phase 2
- Conditions
- Health Condition 1: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvementHealth Condition 2: M059- Rheumatoid arthritis with rheumatoid factor, unspecified
- Registration Number
- CTRI/2023/05/052317
- Lead Sponsor
- GOVERNEMNT SIDDHA MEDICAL COLLEGE, PALAYAMKOTTAI
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Those who are willing to participate in the study.
2.RA factor test : positive
3.Anti CCP test :positive
4.CRP Test
5. DAS score 28 >2.6
Exclusion Criteria
1.Age: Below 34 ; Above 60
2.Other degenerative joint disease like osteoarthritis, sero negative spondyloarthritis, ankylosing spondylitis.
3.Infectious joint disease like tuberculosis,chronic poly arthritis in chickungunia viral infection.
4.Metabolic joint disease
5.Pregnancy and lactating mothers
6.Chronic renal and liver disease patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Symptomatic relief i.e, reduction in pain, swelling, movement difficulties(DAS score) <br/ ><br>2.Improve the physical movements and relieve the disabilities and structural defects of hand and legs as much as possible <br/ ><br>3.Reduce any extra articular involvement of the disease if any. <br/ ><br>Timepoint: 45 days
- Secondary Outcome Measures
Name Time Method 1.Prevent recurrence of the disease by advising, continuous and periodic intake of medicine and dietary regimen. <br/ ><br>2.Proper monitoring of patient and disease state with relevant blood test and immunological assays. <br/ ><br>3.To collect various Siddha literatures and modern journals for literature review on UTHIRAVATHA SURONITHAM. <br/ ><br>4. To perform physicochemical, phytochemical, bio chemical analysis <br/ ><br>5.To evaluate safety profile for acute and sub-acute toxicity <br/ ><br>6.To evaluate pharmacological activities <br/ ><br>7.To perform in-vitro, in-vivo studies. <br/ ><br>8.To evaluate anti microbial activity <br/ ><br>9.To perform cell line studies <br/ ><br>10.To evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri) in uthiravatha suronitham during trial period. <br/ ><br>11.To evaluate modern parametric changesTimepoint: 6 months