The short-term effects of full-mouth or quadrant-wise applied non-surgical periodontal therapy on immune response, oxidation process, and clinical parameters

Phase 4

Completed

• Conditions: periodontitis; periodontal disease, oxidative stress, root planing, tumor necrosis factor alpha

• Registration Number: TCTR20240416007
• Lead Sponsor: Sebnem bilir ikiz

Brief Summary

Both treatment protocols were efficient in the treatment of periodontitis but the FM therapy significantly reduced periodontal tissue inflammation, as evidenced by changes in both clinical and biochemical parameters in our study. However, it may be seen that FM therapy is more effective during short-term recovery, maybe the reason could be attributed to TAS and TNF alfa changes following FM therapy.

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-11-30
• Study Start: 2024-04-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

aged 25 and above, systemically healthy and lifelong non smokers ,at least had 20 teeth, diagnosis of moderate-advanced periodontitis

Exclusion Criteria

pregnant or lactating females, had a diagnosis of any systemic disease as diabates, had removable prosthesis and had undergone periodontal treatment or used antibiotics in the last 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total antioxidant status, total oxidant status 3 months ELISA kit as mmol Trolox Equivalents/L ELISA kit as micromoles of hydrogen peroxide equivalents per liter

Secondary Outcome Measures

Name	Time	Method
Clinical measurements, Tumor Necrosis Factor alpha 3 months ELISA kit (Eastbiopharm - Human TNF-alpha Platinum ELISA, Cat No: CK-E10110) The outcomes were quantified and reported in nanograms per liter (ng/L).