ong-term effect of periodontal treatment on gingival crevicular fluid level of Cathepsin K in chronic periodontitis patients with type 2 diabetes mellitus
Completed
- Conditions
- Periodontal disease is the most common oral disease leads to soft tissue and alveolar bone destruction. Diabetes mellitus increase risk of periodontitis.PeriodontitisCathepsin KGingival crevicular fluid
- Registration Number
- TCTR20190621003
- Lead Sponsor
- Faculty of Dentistry, Mahidol university
- Brief Summary
Periodontal treatment decreased CTSK in GCF, however, CP+DM group had a significantly higher amount of CTSK than CP group. However, good compliance with SPT in CP+DM and CP groups maintained good periodontal health, with comparable CTSK levels in GCF in both groups. All three groups had detectable CTSK in saliva.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 23
Inclusion Criteria
1. Patients with chronic periodontitist
2. more than 30 percent of site with probing depth more than 5 mm with gingival inflammation
Exclusion Criteria
1.Any systemic disease that effect progression and healing periodontal disease or have to take antibiotic premedication
2.On medication that effect to periodontium
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cathepsin K baseline, 3 months from baseline, 3 years from baseline picograms/enzyme-linked immunosorbent assay ,Cathepsin K concentration baseline, 3 months from baseline, 3 years from baseline picograms per microlitre /enzyme-linked immunosorbent assay
- Secondary Outcome Measures
Name Time Method Probing depth baseline, 3 months from baseline, 3 years from baseline millimetre/PCPUNC 15, Hu-Friedy,Clinical attachment level baseline, 3 months from baseline, 3 years from baseline millimetre/PCPUNC 15, Hu-Friedy