Impact of treatment of chronic periodontitis on the serum levels of prohepcidin in patients with chronic kidney disease
- Conditions
- Chronic periodontitis (CP)chronic kidney disease (CKD)ProhepcidinOral HealthGingivitis and periodontal diseases
- Registration Number
- ISRCTN59866656
- Lead Sponsor
- Federal University of Juiz de Fora (Universidade Federal de Juiz de Fora [UFJF]) (Brazil)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 56
1. Patients with CP, allocated to one of two groups depending on CKD status
1.1. CKD group:
1.1.1. Patients with CKD at stages 3 to 5 and undergoing conservative treatment
1.1.2. Recruited from the PREVENRIM, a CKD prevention clinic at the Interdisciplinary Nucleus of Studies, Research and Treatment in Nephrology (NIEPEN) of the Universidade Federal de Juiz de Fora (UFJF)
1.2. Control patients:
1.2.1. Patients with no systemic disease from the Periodontology Clinic of the School of Dentistry at UFJF
2. Over 18 years of age, either sex
2. Minimum of 20 natural teeth and without periapical lesions
3. Have received no periodontal, antimicrobial, or anti-inflammatory treatment within the last 6 months
4. Have not used steroids or immunosuppressant drugs within the last 6 months
1. Pregnant or breast feeding women
2. Smokers or ex-smokers who had quit smoking within the last 10 years
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Inflammatory markers, assessed at baseline and 3 months post-PT<br>1. C-reactive protein (us-CRP)<br>2. Interleukin-6 (IL-6)<br>3. Prohepcidin
- Secondary Outcome Measures
Name Time Method Biochemical analyses from blood sample in EDTA, at baseline and 3 months post-PT<br>1. Complete haemogram (automated Coulter STKS)<br>2. Serum iron (ferrozine)<br>3. Ferritin (electrochemiluminescence)<br>4. Transferrine saturation index (labtest ferrozine)