The effect of treatment of periodontitis on markers of cardiovascular diseases

• Conditions: 10004018; cardiovascular diseases; metabolic syndrome; 10028593; 10018424

• Registration Number: NL-OMON32003
• Lead Sponsor: niversiteit van Amsterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

The patients must show on dental radiograph periodontal bone loss of > 1/3 of the total length of the root on > 1 tooth per quadrant.

Exclusion Criteria

1) No chronic diseases as CVD or diabetis with exception of periodontitis
2) No acute diseases or infections in the last 4 weeks.
3) No pregnancy.
4) No chronic medications
5) No chronic medications that can have an effect on the periodontal tissues (e.g. antibiotics) in the past 6 months and no anti-inflammatory drugs (NSAID's) in the past 4 weeks.
6) No hypersensitivity or controindication for the use of amoxycillin and/or metronidazol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Probing pocket depth, bleeding on probing, change in attachment level, level of<br /><br>subgingival bacterial recolonisation, plasma levels of CRP, PAI-1, fibrinogen,<br /><br>von Willebrand factor (vWF), Leucocytes, Vitamin C, Insulin and Glucose.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Proteomes of saliva and serum</p><br>