Dental Health in Recurrent Miscarriage
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- recurrent miscarriage
研究概览
简要总结
Oral infections can trigger the production of pro-inflammatory mediators that may be risk factors for miscarriage. The investigators investigated whether oral health care patterns that may promote or alleviate oral inflammation were associated with the history of miscarriage in Turkish women.
详细描述
Power analysis was performed with the G-Power software package to determine sample size.
To cover possible data loss, 10% of a group were added to each group. Medical and dental examination will be performed both of control and experimental groups. In dental examination decayed, missing, or filled teeth (DMFT) index will be used according to World Health Organization (WHO 1997) criteria. All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II).
To analyze the correlation between oral health status and miscarriage linear regression test and for comparison of both the groups (case and control), two sample t test and chi square test were used.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •history of at least two unexplained recurrent miscarriage below 20th week of pregnancy
- •systemically healthy females with at least two normal births
- •no poor obstetric history such as preeclampsia and premature birth
排除标准
- •history of thyroid disease, hyperprolactinemia, antiphospholipid syndrome, systemic lupus erythematosus, autoimmune diseases, thrombophilia, diabetes mellitus, uterine/cervical abnormalities, polycystic ovary syndrome, active liver disease, cardiovascular disease, premature ovarian failure, acute or chronic upper respiratory tract diseases, IVF pregnancy, multiple pregnancy, preeclampsia, arterial or venous embolism, infection,
- •habit of smoking, alcohol, drug or caffeine,
- •abnormal embryo karyotype,
- •infection with hepatitis B or C, and HIV,
- •chromosomal abnormalities,
- •dental fluorosis,
- •fluoride supplements,
- •orthodontic appliances,
- •body mass index ≥ 30 kg / m2
- •age of the partner is found to be over 40
结局指标
主要结局
recurrent miscarriage
时间窗: below 20th week of pregnancy
If abortion material is obtainable, it will be genetically evaluated for chromosomal abnormalities. At least 8 weeks after termination of pregnancy, karyotype analysis of both couples and thrombophilia panel ( Factor V Leiden, prothrombin gene mutation G20210A, protein S/Protein C/antithrombin deficiency and MTHFR mutations) in the study group will be requested.
次要结局
- Bleeding Examination(1 Day)
- Dental Examination(1 Day)
- Periodontal Examination(1 Day)
- Clinical attachment level(1 Day)
- Plaque Examination(1 Day)
- Gingival Examination(1 Day)
研究者
Gul Yildiz Telatar
Principal Investigator
Recep Tayyip Erdogan University Training and Research Hospital