The influence of symptom provocation on glutamate in obsessive-compulsive disorder - a functional magnetic resonance spectroscopy study

Completed

Conditions: alcoholism
contamination fear | alcohol addiction
Obsessive-compulsive disorder
10021563

Registration Number: NL-OMON49350

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Patients diagnosed with OCD (18 - 70 years) according to the DSM-5 criteria
(American Psychiatric Association, 2013), with a Y-BOCS score of * 16.

Age, gender and education matched healthy control participants free from
psychiatric, neurological or severe somatic disorders.

Exclusion Criteria

Contraindications for MRI examination; e.g. metal in the body, claustrophobia.

Problems with or shortness of breath when lying flat for 60 minutes.

Traumatic brain injury involving a cerebral contusion with 1) loss of
consciousness for more than 15 minutes and 2) post-traumatic amnesia of more
than one hour.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The change in the concentration of glutamate in the LOC when viewing<br /><br>disorder-specific visual stimuli (versus neutral stimuli) in patients with OCD<br /><br>compared to healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* The change in the concentration of GABA in the LOC when viewing<br /><br>disorder-specific visual stimuli (versus neutral stimuli) in patients with OCD<br /><br>compared to healthy controls.<br /><br><br /><br>* Changes in brain activity in the LOC when viewing disorder-specific visual<br /><br>stimuli (versus neutral stimuli) by patients with OCD and healthy controls.<br /><br><br /><br>* Relationship between change in glutamate and GABA concentration and change in<br /><br>brain activity in the LOC when viewing disorder-specific visual stimuli in<br /><br>patients with OCD compared to healthy control participants.</p><br>