Brain glutamate levels in patients who experienced a psychosis: The GLUP study

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:;Inclusion criteria for all subjects (patients and healthy controls):
* 16-40 years old.
* Written informed consent of the subject;Patients who experienced a psychosis:
* Psychosis (ICD-10 criteria for any functional psychotic illness: F10-19, excluding coding F1x.0 for Acute intoxication; F20-29 and F30-39, psychotic codings).

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:;General exclusion criteria for all individuals:
- Use of certain drugs and medication
- Any previous neurosurgery or neurological disorder, including epilepsy
- Any contraindications for MRI
- Subjects who do not fully comprehend the purpose or are not competent to make a rational decision whether or not to participate
- Patients who were admitted to a psychiatric unit involuntarily after being given an *inbewaringstelling* (IBS). Patients with *rechterlijke machtigingen* (RM) may be included, but only if they are mentally competent (see section on mental competence and decisional capacity above). The reasons for including these patients are that this will increase the likelihood of attaining the projected number of study participants and that inclusion of these patients will contribute to assembling a study population representative of all Dutch patients. ;Additional exclusion criteria for healthy controls:
- Current Axis-I psychiatric disorder

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameter:<br /><br>- High-resolution brain glutamate levels.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters:<br /><br>- Symptom severity in patients who experienced a psychosis<br /><br>o Short cognitive test battery<br /><br>o Positive and negative symptoms (Positive and Negative Symptoms Scale (PANNS))<br /><br>o Functional impairment (using the Manchester Short Assessment of Quality of<br /><br>Life)<br /><br>- Structural (brain volumes) and functional (resting state BOLD signal) brain<br /><br>parameters.<br /><br>- (epi)Genetic variation in glutamatergic genes. </p><br>