europlasticity of brain glutamate and glutamine and treatment response in alcoholism
- Conditions
- F10.2
- Registration Number
- DRKS00003439
- Lead Sponsor
- Zentralinstitut für Seelische GesundheitKlinik für Abhängiges Verhalten und Suchtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Legally effective, written informed consent for participation within the study, including ability to communicate with the researchers
Alcohol dependent subjects:
- Diagnose of alcohol dependence according to ICD-10 and DSM-IV
Healthy controls:
- no or minimal consumption of alcohol,
- laboratory parameters sensitive for alcohol within normal range
Actual psychiatric disorder (Axis I) according to DSM-IV / ICD-10 (assessed with SCID-I) except nicotine abuse or nicotine dependence and alcohol dependence for patients
- Positive drugscreen (opiates, cannabinoids, benzodiazepines, barbiturates, cocaine, amphetamine),
- actual treatment with psychoactive medication,
- MR contraindication (e.g. pacemaker, metallic or electronic implants, metal splinters…)
- Severe physical disorders (liver-cirrhosis, severe diabetes),
- former psychotic disorder,
- actual suicidal tendency or endangerment of others
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method concentrations of glutamate, glutamine and GABA in the anterior cingulate cortex are assessed with MR-Spectroscopy at the beginning of acute alcohol withdrawal, after fife days of abstinence and after two weeks of abstinence<br><br><br><br>
- Secondary Outcome Measures
Name Time Method associations of metabolite concentrations in the anterior cingulate cortex at the beginning of acute alcohol withdrawal, after five days of abstinence and after two weeks of abstinence with cue-reactivity to alcoholrelated stimuli. Cue-reactivity will be assessed using functional Magnetic Resonance Imaging (fMRI).<br>