Glutamate and cognition in adults with 22q11DS
Completed
- Conditions
- 22q11 deletion syndromecognition
- Registration Number
- NL-OMON29680
- Lead Sponsor
- Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
• Confirmed diagnosis of 22q11DS established by FISH, microarray or MLPA analysis.
•Age 18 and older and mentally competent to give informed consent.
Exclusion Criteria
•Other chromosomal abnormalities
•Current substance abuse / dependence
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameter will be striatal and ACC glutamate concentrations as measured with [1]H MRS after a glutamate challenge and after placebo.
- Secondary Outcome Measures
Name Time Method A secondary outcome measure is cognitive functioning, measured with a standardized cognitive battery (CANTAB). A cognitive composite score will be computed using the mean scores of the CANTAB subtests. This score will represent cognitive functioning.