Assessment of Left Ventricular Diastolic Function in Patients With Atrial Fibrillation

• Conditions: Atrial Fibrillation

• Registration Number: NCT04654806
• Lead Sponsor: Yonsei University

Brief Summary

This study is a single-center, prospective cohort study to investigate non-invasive method to assess left ventricular diastolic function using echocardiography. Patients with AF who are referred radiofrequency catheter ablation (RFA) will be included prospectively. Transthoracic echocardiography will be performed during, immediately before RFA and with no cardiovascular medication taken between the exams so that the loading conditions during catheterization and echocardiography are as similar as possible. We will validate previously proposed echocardiographic parameters and creat an algorithm to identify the relationship between echocardiographic parameters of diastolic function and invasively measured LA pressure in patients with atrial fibrillation.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-25
• Study First Submitted: 2020-11-26
• Study First Submitted QC: 2020-12-02
• Study First Posted: 2020-12-04
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-09
• Last Update Posted: 2022-05-10
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Adult ≥ 19 year-old
• Patients who scheduled to perform radiofrequency catheter ablation for atrial fibrillation
• Patients who had paroxysmal, persistent, or chronic AF
• Patients provided with the written, informed consent to participate in this study

Exclusion Criteria

• Patients with prosthetic valve
• Life expectancy < 12 months
• Subject who the investigator deems inappropriate to participate in this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association between mean left atrial pressure and echocardiographic parameters	up to 12 weeks after collecting all data	Correlation between echocardiographic parameters or algorithm to estimate invasively measured left atrial pressure.; Echocardiographic parameters: E/A ratio, E velocity, e' velocity, E/e', IVRT. LV strain, RV strain,, LA strain, Vp, E/Vp, LA volume index, TV V max, and Peak acceleration rate of mitral E velocity

Trial Locations

Locations (1)

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of