Assessment of Left Ventricular Diastolic Function in Patients With Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Association between mean left atrial pressure and echocardiographic parameters
研究概览
简要总结
This study is a single-center, prospective cohort study to investigate non-invasive method to assess left ventricular diastolic function using echocardiography. Patients with AF who are referred radiofrequency catheter ablation (RFA) will be included prospectively. Transthoracic echocardiography will be performed during, immediately before RFA and with no cardiovascular medication taken between the exams so that the loading conditions during catheterization and echocardiography are as similar as possible. We will validate previously proposed echocardiographic parameters and creat an algorithm to identify the relationship between echocardiographic parameters of diastolic function and invasively measured LA pressure in patients with atrial fibrillation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ≥ 19 year-old
- •Patients who scheduled to perform radiofrequency catheter ablation for atrial fibrillation
- •Patients who had paroxysmal, persistent, or chronic AF
- •Patients provided with the written, informed consent to participate in this study
排除标准
- •Patients with prosthetic valve
- •Life expectancy < 12 months
- •Subject who the investigator deems inappropriate to participate in this study
结局指标
主要结局
Association between mean left atrial pressure and echocardiographic parameters
时间窗: up to 12 weeks after collecting all data
Correlation between echocardiographic parameters or algorithm to estimate invasively measured left atrial pressure. Echocardiographic parameters: E/A ratio, E velocity, e' velocity, E/e', IVRT. LV strain, RV strain,, LA strain, Vp, E/Vp, LA volume index, TV V max, and Peak acceleration rate of mitral E velocity
次要结局
未报告次要终点