Breathing Performance of Healthy Young Adult

Completed

• Conditions: COPD-like; COPD

• Registration Number: NCT04857541
• Lead Sponsor: National Cheng-Kung University Hospital

Brief Summary

The study will recruit subject of healthy adult, COPD-like patient and patient with COPD to investigate the difference of respiratory performance. We will measure the body composition, respiratory muscle force, pulmonary function and performance of voluntary cough. The muscle thickness of abdominal muscle and diaphragm, assessment of diaphragm during different breathing pattern and the muscle activation during voluntary cough will also being determined. We hypothesized that there will be a significantly different between three group on the performance of voluntary cough, and the correlation between each variable will be further investigated.

Detailed Description

The specific aims of the study are:

1. difference of respiratory muscle performance between three groups

2. the correlation between respiratory symptom and pulmonary functional test

3. difference of functional respiratory performance (peak cough flow of voluntary cough) between three groups

4. muscle activation of abdominal muscle and diaphragm during performing voluntary force

5. performance of diaphragm under different breathing load

Study Timeline

• Study First Submitted: 2021-04-15
• Study First Submitted QC: 2021-04-20
• Study First Posted: 2021-04-23
• Study Start: 2021-05-11
• Primary Completion: 2021-05-13
• Study Completion: 2022-04-20
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-09
• Last Update Posted: 2022-06-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• aged 20 years or above
  • currently not being diagnosis as COPD
  • less than 4 times/week of aerobic exercise

2. COPD-like subject

   Inclusion Criteria:

   • aged 20 years or above
   • currently not being diagnosis as COPD
   • presented of COPD symptoms (coughing, sputum production and dyspnea), last for 3 months and more than 2 years
   • score more than 1 on modified Medical Research Council (mMRC) or COPD Assessment Test (CAT)

3. COPD subject

Inclusion Criteria:

• aged 20 years or above
• currently being diagnosis as COPD
• haven't participated in any pulmonary rehabilitation program in the past three months

Exclusion Criteria

• Untreated comorbidities for COPD
• Postural asymmetries (Scoliosis, length discrepancy of the lower limbs or other previous surgical history of spine)
• Chronic nonspecific lumbopelvic pain
• Gynecological or abdominal surgery in the previous year
• Pregnancy or post-delivery in the previous 6 months
• Neurological or inflammatory disorders
• Any conditions that may interfere with the data collection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak cough flow	baseline	Peak coughing velocity of voluntary cough in liter/second

Secondary Outcome Measures

Name	Time	Method
Respiratory muscle force	baseline	MIP/MEP in cmH2O
Pulmonary function test	baseline	MVV rate in breaths/min
Muscle activation during voluntary force	baseline	aURA/aLRA/aEO/aIOTrA/aD (all the data will be collected through surface EMG and will be presented as maximal voluntary contraction in %)
Diaphragm assessment	baseline	QB_slope/DB_slope/Sniff_slope in cm/s
Muscle thickness during voluntary force	baseline	tRA/tEO/tIO/tTrA/tD in millimeter

Trial Locations

Locations (1)

National Cheng Kung University Hospital; 🇨🇳 Tainan, Taiwan