NCT02186639CompletedNot Applicable
Exhaled Breath Analysis in Patients With COPD by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS)
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Zurich
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- COPD-specific mass spectrometric exhaled breath pattern
Study Overview
Brief Summary
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
Detailed Description
This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC < 0.7) performed within the last 6 months
- •age between 18 and 80 years at study entry
- •healthy controls: normal spirometry
Exclusion Criteria
- •COPD exacerbation within the last 6 weeks
- •any lung disease other than COPD
- •acute inflammatory disease (e.g. common cold) within the last 6 weeks
- •acute or chronic hepatic disease
- •renal failure or renal replacement therapy
Outcomes
Primary Outcomes
COPD-specific mass spectrometric exhaled breath pattern
Time Frame: baseline
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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