Breath Analysis in Chronic Obstructive Lung Disease (COPD)
Completed
- Conditions
- COPD
- Registration Number
- NCT02186639
- Lead Sponsor
- University of Zurich
- Brief Summary
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
- Detailed Description
This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC < 0.7) performed within the last 6 months
- age between 18 and 80 years at study entry
- healthy controls: normal spirometry
Read More
Exclusion Criteria
- COPD exacerbation within the last 6 weeks
- any lung disease other than COPD
- acute inflammatory disease (e.g. common cold) within the last 6 weeks
- acute or chronic hepatic disease
- renal failure or renal replacement therapy
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method COPD-specific mass spectrometric exhaled breath pattern baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Zurich, Pulmonary Division
🇨ðŸ‡Zurich, Switzerland