Exhaled Breath Analysis in Patients With COPD by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS)

University of Zurich1 site in 1 country40 target enrollmentJune 2014

ConditionsCOPD

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: COPD
Sponsor: University of Zurich
Enrollment: 40
Locations: 1
Primary Endpoint: COPD-specific mass spectrometric exhaled breath pattern
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Detailed Description

This is an observational study comparing the volatile organic compounds (VOCs) in exhaled breath between COPD patients and matched control subjects (age, gender, smoking-state). 40 COPD patients (20 non-frequent, 20 frequent exacerbators) and 40 matched controls will be examined by SESI-MS on the composition of exhaled breath for identification of COPD specific markers.

Registry

clinicaltrials.gov

Start Date

June 2014

End Date

November 2017

Last Updated

8 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Zurich

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•confirmed COPD GOLD stage I-IV, based on a post-bronchodilator spirometry (FEV1/FVC \< 0.7) performed within the last 6 months
•age between 18 and 80 years at study entry
•healthy controls: normal spirometry