Breath Analysis in Lung Fibrosis

Completed

• Conditions: Idiopathic Lung Fibrosis; Idiopathic Pulmonary Fibrosis
• Interventions: Other: No intervention

• Registration Number: NCT02437448
• Lead Sponsor: University of Zurich

Brief Summary

The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-04-28
• Study First Submitted QC: 2015-05-06
• Study First Posted: 2015-05-07
• Study Start: 2015-06
• Primary Completion: 2018-12
• Study Completion: 2018-12
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-01
• Last Update Posted: 2020-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

1. Clinical symptoms consistent with IPF
2. Age 40 through 80 years
3. Diagnosis of UIP or IPF by HRCT and surgical lung biopsy as outlined in table 1. Only patients fulfilling the category "YES" will be included in the study.
4. Extent of fibrotic changes (honeycombing, reticular changes) greater than extent of emphysema on HRCT scan
5. No features supporting an alternative diagnosis

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Exclusion Criteria

1. Acute exacerbation within the last 6 weeks.
2. Any relevant lung disease other than pulmonary fibrosis.
3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks.
4. Acute or chronic hepatic disease.
5. Renal failure or renal replacement therapy.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Idiopathic lung fibrosis	No intervention	20 IPF patients
Controls	No intervention	20 subjects with no apparent lung disease and normal lung function testing. Matched for gender, age and smoking history.

Primary Outcome Measures

Name	Time	Method
IPF-specific mass spectrometric profile of volatile organic compounds of exhaled breath analysis (markers of IPF in exhaled breath)	1 day

Trial Locations

Locations (1)

Pulmonary Division, University Hospital of Zurich; 🇨🇭 Zurich, Switzerland