NCT02437448已完成不适用
Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry (SESI-MS) in Patients With Pulmonary Fibrosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- IPF-specific mass spectrometric profile of volatile organic compounds of exhaled breath analysis (markers of IPF in exhaled breath)
研究概览
简要总结
The aim of the study is to answer the question whether a disease specific profile of breath in patients with idiopathic lung fibrosis can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical symptoms consistent with IPF
- •Age 40 through 80 years
- •Diagnosis of UIP or IPF by HRCT and surgical lung biopsy as outlined in table
- •Only patients fulfilling the category "YES" will be included in the study.
- •Extent of fibrotic changes (honeycombing, reticular changes) greater than extent of emphysema on HRCT scan
- •No features supporting an alternative diagnosis
排除标准
- •Acute exacerbation within the last 6 weeks.
- •Any relevant lung disease other than pulmonary fibrosis.
- •Acute inflammatory disease (e.g. common cold) within the last 6 weeks.
- •Acute or chronic hepatic disease.
- •Renal failure or renal replacement therapy.
结局指标
主要结局
IPF-specific mass spectrometric profile of volatile organic compounds of exhaled breath analysis (markers of IPF in exhaled breath)
时间窗: 1 day
次要结局
未报告次要终点
研究者
Malcolm Kohler
Prof
University of Zurich
研究点 (1)
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