Breath Analysis in Healthy Controls

Completed

• Conditions: Exhaled Breath; Mass Spectrometry; Healthy Subjects
• Interventions: Other: No intervention

• Registration Number: NCT02595632
• Lead Sponsor: University of Zurich

Brief Summary

The purpose of this study is to detect a specific profile of breath in healthy subjects by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-11
• Study First Submitted: 2015-11-02
• Study First Submitted QC: 2015-11-02
• Study First Posted: 2015-11-03
• Primary Completion: 2020-08
• Study Completion: 2020-08
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-01
• Last Update Posted: 2020-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 183

Inclusion Criteria

1. Normal spirometry (forced expiratory volume in 1 second (FEV1) > 80%, forced vital capacity (FVC) > 80%, FEV1/FVC > 70%.).
2. Age between 18 and 90 years at study entry.

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Exclusion Criteria

1. Presence of an active malignancy.
2. Presence of any lung disease (e.g. asthma, chronic obstructive pulmonary disease (COPD), sarcoidosis)
3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks.
4. Acute or chronic hepatic disease.
5. Renal failure or renal replacement therapy.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy	No intervention	Healthy subjects with no apparent lung disease and normal lung function testing.

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the mass spectrometric exhaled breath pattern of healthy subjects.	1 day, single measurement, no follow up

Trial Locations

Locations (1)

University Hospital Zurich, Pulmonary Division; 🇨🇭 Zurich, Switzerland