Prevalence of Positive Reactions in Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Prevalence of positive reaction in APT in children with food allergy-related gastrointestinal symptoms
研究概览
简要总结
Positive reactions in Atopy patch test in children with food allergy-related gastrointestinal symptoms
详细描述
The prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. Little is known about the diagnostic accuracy of atopy patch tests(APT) in the clinical practice. APT seems to have a better specificity than the IgE methods and seems to reflect late-phase clinical reactions.The aims of this study were to evaluate:
(i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who had history of suspected food allergy-related gastrointestinal symptoms eg. nausea and vomiting, diarrhea, abdominal pain or hematochezia after ingesting some food.
- •Age 1 month-18 yrs
- •Elimination diet was done at least 7 days before starting the study
- •Written informed consent was obtained from the parents of each child enrolled in the study
排除标准
- •Who have dermographism
- •Who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease
- •Pregnant women
- •Who have severe eczema
- •Who receive antihistamine, topical steroid and systemic steroid > 20 mg/day withiin 7 days prior study
研究组 & 干预措施
Atopy patch test
Atopy patches were applied on food allergy patient's back for 48 hrs then the patches were removed. Reaction was evaluated at 48 and 72 hrs after applying atopy patch test
干预措施: Atopy patch test with food allergen (Device)
结局指标
主要结局
Prevalence of positive reaction in APT in children with food allergy-related gastrointestinal symptoms
时间窗: 3 days
To evaluate (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test.
次要结局
- Comparisons atopy patch test reaction between lyophilized allergen and commercial allergen(3 days)
研究者
Nualanong Visitsunthorn
Professor
Mahidol University