Research for identifying aggravating factors and establishing effective interventions to prevent dementia progressio

Not Applicable

• Conditions: Dementia (Alzheimer' s disease, dementia with Lewy bodies, frontotemporal lobar degeneration, argyrophilic grain disease, limbic predominant age-related TDP-43 encephalopathy)

• Registration Number: JPRN-UMIN000052032
• Lead Sponsor: Fukushima Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-01
• Last Update Posted: 17 October 2023
• Study Completion: 2026-07-31

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

Not provided

Exclusion Criteria

Patients with schizophrenia, alcoholism, and extensive cerebrovascular disease

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MMSE total scores in every 12 months.Presence or absence of a drop of 3 points or more from the baseline.

Secondary Outcome Measures

Name	Time	Method
Clinical dementia rating, independence rating score in daily life of dementia, Neuropsychiatric inventory (NPI), neuropsychological assessments, hippocampal atrophy on MRI, arterial spin labeling, cerebral blood flow on SPECT, dopamine transporter imagings, amyloid PET, neuropathological findings