NCT00631501Unknown不适用
Doxycycline for Lateral Epicondylalgia - RCT
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Pain (VAS)
研究概览
简要总结
Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.
This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.
Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-65
- •Pain at the lateral side of the elbow ≥8 weeks
- •Local tenderness on palpation of the lateral epicondyle
- •Pain on resisted extension of the wrist
排除标准
- •Rheumatic disorder
- •History of fibromyalgia or generalised pain
- •Elbow surgery (on the painful side)
- •Active infection
- •Glucocorticoid treatment during the duration of symtoms of epicondylalgia
- •NSAID use within 1 w before presentation and during the study
- •Pregnancy
- •Taking drug that might interact with doxycycline
研究组 & 干预措施
2
Placebo Comparator
干预措施: Placebo (Drug)
Doxycycline
Experimental
100 mg twice daily
干预措施: Doxycycline (Drug)
结局指标
主要结局
Pain (VAS)
次要结局
未报告次要终点
研究者
研究点 (1)
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