The effect of doxycycline on Matrix Metalloproteinase expression and activity in the abdominal aneurysm.
Completed
- Conditions
- Abdominal aortic aneurysmAneurysma van de abdominale aorta
- Registration Number
- NL-OMON28262
- Lead Sponsor
- Dr. JHN LindemanDept Vascular SurgeryLUMC K6RPObox 96002300 RC LeidenThe NetherlandsLindeman@lumc.nl
- Brief Summary
indeman JH, Abdul-Hussien H, Schaapherder AF, van Bockel JH, von der Thüsen JH, Roelen DL, Kleemann R. Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurismal from atherosclerotic aorta: IL-6 and IL-8 dominated inflammatory responses prevail in the human aneurysm. Clin Sci (Lond). 2007; [Epub ahead of print] <br> Abdul-Hussien H, Soekhoe RG, Weber E, von der Thüsen JH, Kleemann R, Mulder A, van Bockel JH, Hanemaaijer R, Lindeman JH. Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases. Am J Pathol. 2007;170:809-17.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Indication for open aneurysm repair.
Exclusion Criteria
Impaired kidney and or liver dysfunction
doxycycline intolerance.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MMP-1, 8, 13 mRNA and protein expression.
- Secondary Outcome Measures
Name Time Method Cathepsin K,L and S mRNA protein expression, expression of other MMPs and the respective inhibitors.