NL-OMON28262已完成不适用
The effect of doxycycline on Matrix Metalloproteinase expression and activity in the abdominal aneurysm.
Dr. JHN LindemanDept Vascular SurgeryLUMC K6RPObox 96002300 RC LeidenThe NetherlandsLindeman@lumc.nl0 个研究点目标入组 60 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
indeman JH, Abdul-Hussien H, Schaapherder AF, van Bockel JH, von der Thüsen JH, Roelen DL, Kleemann R. Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurismal from atherosclerotic aorta: IL-6 and IL-8 dominated inflammatory responses prevail in the human aneurysm. Clin Sci (Lond). 2007; [Epub ahead of print]
Abdul-Hussien H, Soekhoe RG, Weber E, von der Thüsen JH, Kleemann R, Mulder A, van Bockel JH, Hanemaaijer R, Lindeman JH. Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases. Am J Pathol. 2007;170:809-17.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Indication for open aneurysm repair.
排除标准
- •Impaired kidney and or liver dysfunction
- •doxycycline intolerance.
研究者
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