GnRH agonist trigger VS HCG trigger for final oocyte maturation in GnRH antagonist protocol ICSI cycles
Not Applicable
- Conditions
- Fertility-female
- Registration Number
- PACTR202209544173620
- Lead Sponsor
- Ain Shams University Maternity Hospital and Adam International Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 82
Inclusion Criteria
o Female age between 18 and 40 years.
o Primary or secondary infertility.
o Baseline FSH and LH lower than 12 IU/l.
o Body mass index (BMI) between 18 and 40kg/m2.
Exclusion Criteria
o Ovarian endometriosis.
o Ovarian cysts before induction.
o Known endocrinal abnormalities (like hypo or hyperthyroidism, hyperprolactinemia, pituitaryabnormalities).
o AMH = 10 ng/ml.
o Duration of induction 6 days or less. or Duration of induction more than 16 days.
o E2 drop during induction.
o Last E2 level before trigger more than 10000pg/ml.
o Immature oocytes syndrome.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ovarian hyperstimulation syndrome OHSS rate
- Secondary Outcome Measures
Name Time Method 1-Oocyte maturation rate Percentage of Mature oocytes (MII) retrieved.<br>2-Fertilization rate Fertilization rate (FR) is percentage of transformation of micro injected oocytes into two pronuclei<br>3-Blastulation rate Blastulation rate is defined as the total number of blastocysts in a cycle (including those transferred and<br>cryopreserved) divided by the total number of fertilized oocytes (Jones et al., 2020).<br>4-Biochemical pregnancy rate Biochemical pregnancy is a pregnancy diagnosed only by the detection of beta hCG in serum or urine <br>5-Clinical pregnancy rate Clinical pregnancy rate is the number of clinical pregnancies expressed per 100 initiated cycles, aspiration cycles or embryo transfer cycles. When clinical pregnancy<br>rates are recorded, the denominator (initiated, aspirated orembryo transfer cycles) must be specified<br>6-Miscarriage rate Miscarriage is generally defined as a nonviable intrauterine pregnancy up to 20 weeks gestation