Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients

Completed

• Conditions: Seborrheic Dermatitis; Psoriasis Vulgaris; Microbial Colonization
• Interventions: Other: Microbiota

• Registration Number: NCT03807453
• Lead Sponsor: Istanbul Medeniyet University

Brief Summary

A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-01-05
• Study First Submitted QC: 2019-01-14
• Study First Posted: 2019-01-17
• Study Start: 2019-04-25
• Primary Completion: 2019-06-18
• Study Completion: 2019-06-18
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-08
• Last Update Posted: 2020-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients with scalp psoriasis
2. Patients with seborrheic dermatitis
3. Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months

Exclusion Criteria

1. Patients who do not want to participate in the study
2. Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
3. Those with chronic diseases that may affect skin microbiome
4. Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
5. Patients who are using topical or systemic drugs for their illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Psoriasis Vulgaris patients-Lesion free	Microbiota	-
Control Group	Microbiota	-
Psoriasis Vulgaris patients-Lesion	Microbiota	-
Seborrheic Dermatitis-Lesion	Microbiota	-
Seborrheic Dermatitis-Lesion free	Microbiota	-

Primary Outcome Measures

Name	Time	Method
The scalp microbiota of the patients with psoriasis and seborrheic dermatitis	6 months	The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment.; The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.

Secondary Outcome Measures

Name	Time	Method
The differences between the scalp microbiota of different countries	6 months	Does the microbiota of the patients change between the countries? To our knowledge, there is no similar studies in present. Presenting the scalp microbiome of Turkish population can be a start to understand whether there is a difference in terms of the countries.

Trial Locations

Locations (1)

Melek Aslan Kayıran; 🇹🇷 Istanbul, Turkey