Comparison of Scalp Microbiota of the Patients With Psoriasis Vulgaris and Seborrheic Dermatitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The scalp microbiota of the patients with psoriasis and seborrheic dermatitis
研究概览
简要总结
A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with scalp psoriasis
- •Patients with seborrheic dermatitis
- •Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months
排除标准
- •Patients who do not want to participate in the study
- •Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
- •Those with chronic diseases that may affect skin microbiome
- •Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
- •Patients who are using topical or systemic drugs for their illness
结局指标
主要结局
The scalp microbiota of the patients with psoriasis and seborrheic dermatitis
时间窗: 6 months
The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment. The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.
次要结局
- The differences between the scalp microbiota of different countries(6 months)
研究者
Melek Aslan Kayıran
Dermatologist, M.D.
Istanbul Medeniyet University