How Do Novel Oxygenation Indices Change With Trendelenburg Position in Robot-Assisted Laparoscopic Surgeries?
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Oxygenation indices
研究概览
简要总结
In this study, changes in new oxygenation indices investigated by Asar et al. will be compared with conventional oxygenation and saturation indices in patients undergoing robot-assisted laparoscopic surgery due to pneumoperitoneum and Trendelenburg position.
详细描述
During the intraoperative period, optimal oxygenation should be achieved while avoiding the harmful effects of hypoxia and hyperoxia in patients. The PaO2/FiO2 and SpO2/FiO2 ratios have been traditionally used to assess this condition. Subsequently, oxygenation indices incorporating mean airway pressure have been developed, such as the oxygenation index (OI = (FiO2 × Pmean) / PaO2) and oxygenation saturation index (OSI = (FiO2 × Pmean) / SpO2). More recently, Asar et al. have defined 8 novel oxygenation indices using mean power (MP) and driving pressure (DP) instead of Pmean (OSI-MPtot, OI-MPtot, OSI-ΔPinsp, OI-ΔPinsp, OSI-MPdyn, OI-MPdyn, PaO2/(FiO2xPEEP), and SpO2/FiO2xPEEP). They compared the predictive power of these new indices for intensive care unit (ICU) mortality in COVID-ARDS (C-ARDS) patients with conventional oxygenation indices (PaO2/FiO2, SpO2/FiO2, OI, OSI). OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices were found to have the highest predictive power for ICU mortality. However, there is currently no study investigating the changes of these new indices during the intraoperative period.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA (American Society of Anesthesiologists) class I-III
- •Age between 18-75 years
- •Signed informed consent form
排除标准
- •Diagnosis of COPD (Chronic Obstructive Pulmonary Disease) and asthma
- •History of thoracic surgery
- •Body mass index (BMI) > 35
- •Development of hemodynamic instability or desaturation (SpO2 < 92) during the operation
结局指标
主要结局
Oxygenation indices
时间窗: during the surgery and immediately after the surgery (approximately 3 hours to 6 hours)
This study aims to investigate the effects of Trendelenburg position and pneumoperitoneum on OSI (oxygenation saturation index) in ASA I-III patients undergoing robot-assisted laparoscopic surgery.
次要结局
- Arterial blood gas parameters(during the surgery and immediately after the surgery (approximately 3 hours to 6 hours))
- Mechanical ventilator parameters(during the surgery and immediately after the surgery (approximately 3 hours to 6 hours))
- Hemodynamic parameters(during the surgery and immediately after the surgery (approximately 3 hours to 6 hours))
研究者
Furkan Tontu
Doctor of Anesthesiology and Reanimation
Başakşehir Çam & Sakura City Hospital